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Chancroid is more commonly seen in men than in women, specifically uncircumcised males.

Chancroid is a sexually transmitted disease (STDs) caused by a bacterium called Hemophilus ducreyi. The bacteria are excess likely to enter the sexual organs at the point of a pre-existing injury, such as a tiny cut or scratch. Chancroid can be transmitted in two ways first sexually through skin-to-skin contact with open sore or sores and second non-sexually if a pus-like fluid from the ulcer is in contact with other areas of the body. The disease is found mainly in developing world countries. Localized endemic outbreaks may occur within uniqueted STD and prostitution populations. Chancroid is rare in the United States.

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Autoimmune hemolytic anemia is more likely to occur in middle-aged and older individuals.

Autoimmune hemolytic anemia is a serious, life threatening disease. About half of the time, the cause of autoimmune hemolytic anemia cannot be determined. There are two main types of autoimmune hemolytic anemia: warm antibody hemolytic anemia and cold antibody hemolytic anemia. Autoimmune hemolytic anemia can also be caused by or occur with another disease, such as systemic lupus erythematosus, and rarely it follows the use of certain drugs, such as penicillin. In the warm antibody type, the autoantibodies attach to and destroy red blood cells at temperatures equal to or in excess of normal body temperature. In the cold antibody type, the autoantibodies become most active and attack red blood cells only at temperatures well below normal body temperature.

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