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Acinic cell carcinoma is the fourth most common malignant salivary gland tumor, following mucoepidermoid carcinoma, adenoid cystic carcinoma, and carcinoma ex pleomorphic adenoma; it occurs more frequently than primary squamous cell carcinoma.

Acinic cell carcinoma is a rare, low-grade malignant salivary gland neoplasm. These are malignant tumors of the salivary glands that are dervied from the salivary gland epithelium and characteristically forms glandular acini. It is notable for an unpredictable clinical course with both local recurrence and distant metastase. Approximately, 20% of patients experience local recurrence and 10% distant metastasis, often many years after initial presentation. Pain or tenderness may be present in up to 1/3 of patients. The disease presents as a slow growing mass, sometimes associated with pain or tenderness. A history of exposure to radiation should be sought in patients with salivary gland neoplasms of the larynx or trachea.

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Although adrenocortical carcinoma is rare in adults, it is even more uncommon in children.

Adrenocortical carcinoma is a rare malignancy with a poor prognosis. Adrenocortical carcinoma has no racial predilection. Also called adrenocortical cancer and cancer of the adrenal cortex. Adrenal carcinomas arise from the adrenal cortex and are bilateral in up to 10% of patients. The cause is unknown. About 2 people per million develop this type of tumor. Adrenocortical carcinoma has a bimodal occurrence, with the first peak in the first decade of life and the second peak in the fourth to fifth decades of life. Risk factors for adrenocortical carcinoma include having the following hereditary diseases: Li-Fraumeni syndrome, Beckwith-Wiedemann syndrome, Carney complex.

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